| Big Laurel Branch Wilderness | Carter, TN | 29 miles | SE |
| Lewis Fork Wilderness | Smyth, VA | 31 miles | SE |
| Pond Mountain Wilderness | Johnson, TN | 33.3 miles | SW |
| Little Wilson Creek Wilderness | Grayson, VA | 36 miles | SE |
| Beartown Wilderness | Tazewell, VA | 41.5 miles | NE |
| Unaka Mountain Wilderness | Unicoi, TN | 44.6 miles | SW |
| Little Dry Run Wilderness | Wythe, VA | 48.7 miles | NE |
| Sampson Mountain Wilderness | Greene, TN | 54.1 miles | SW |
| Linville Gorge Wilderness | Burke, NC | 60.5 miles | SE |
| Kimberling Creek Wilderness | Bland, VA | 63.2 miles | NE |
| Linville George Wilderness | Burke, NC | 64.8 miles | SE |
| Peters Mountain Wilderness | Giles, VA | 93.1 miles | NE |
| Mountain Lake Wilderness | Giles, VA | 99 miles | NE |
| Shining Rock Wilderness | Haywood, NC | 106.5 miles | SW |
| Clifty Wilderness | Menifee, KY | 109.3 miles | NW |
| Cherokee Indian Reservation | Jackson, NC | 109.4 miles | SW |
| Cherokee Indian Reservation | Swain, NC | 109.5 miles | SW |
| Middle Prong Wilderness | Haywood, NC | 109.7 miles | SW |
| Cherokee Indian Reservation 3200 Acre Tract | Swain, NC | 118.7 miles | SW |
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